Optimizing for Happiness
By
Thejesh GN
Co-founder of DataMeet and Architect at Mavrix.
At some point I have worked for NextDrop, A Political Campaign, IWP, Infosys etc
What is Happiness?
I couldn't define
What makes me* sad?
Sickness in family (Caregiver Depression)
Sense of whiling away the time
*me == family
What would you do as an Engineer?
Assess the situation
Figure items for restructure/re-engineer
Apply changes
Measure
Optimize
Sickness
What my parents had to go through?
What can I proactively avoid or delay?
What we had in store?
Obesity
Diabetes
Parkinson's Disease (PD)
Let's do some tests
Blood tests - Glycated Haemoglobin (HbA1c), Complete Blood Count (CBC), Lipid Profile, Complete Haemogram, Vitamin D3,Thyroid, Insulin - Fasting
Urine tests - Uric Acid
DNA
DNA
Parkinson's Disease: rs10513789(T;T),gs250
Type 2 Diabetes: rs7754840(C;G), rs13266634(C;T), rs7903146(C;T), rs10811661(T;T) rs12255372(G;T)
What can I do?
Drink coffee and go for a run
On a serious note
Parkinson's Disease
Read a lot about prevention
Consult experts
Apply
Prospective evidence suggests that midlife, regular exercise reduces the subsequent PD risk years later.Neurology. 2011;77(3):288-294. doi:10.1212/WNL.0b013e318225ab66.
This study confirm an inverse association between caffeine intake and the risk of PD, which can hardly by explained by bias or uncontrolled confounding.PMID: 20182023 DOI: 10.3233/JAD-2010-091525
Our findings indicate that higher coffee and caffeine intake is associated with a significantly lower incidence of PD.JAMA. 2000;283(20):2674-2679. doi:10.1001/jama.283.20.2674
Diabetes Type 2
Common so different approach
Wear CGM and Maintain food diary
CGM
CGM
CGM
Everything looks good except
Some food items make my glucose leve shoot up!
Apply common remedies
What do I do now?
How is it going?
Cost?
- 23andMe - $99 each
- FreeStyle Libre Sensor - INR2.5
- Other tests depends on the lab
Tech
- Promethease builds a personal DNA report based on connecting a file of DNA genotypes to the scientific findings cited in SNPedia
- SNPedia is a wikipedia of human genetics
- Nightscout is CGM in the Cloud. It's an open source, DIY project.
- Sample DNA and CGM Reports
Future
- More data - Quantified Self
- Open up Personal Data
- Involve in research
Note
- This is not a medical advice
- I am all healthy. I have no symptoms of anything that I have talked here
- Everything I have talked here is as of yesterday. They keep changing. Keep yourself updated
- Privacy is a huge issue. Careful while chosing the lab. One could use pseudo name/number etc. Specially if you are paying for tests
- Making DNA report public can have an effect on all blood relatives in terms - getting insurance, knowledge of relationships, diseases etc
Thank You
BY Thejesh GN / thejeshgn.com
Watch this movie when you find time. Thank you.
Picture credit: Mi PHAM and RachelBostwick